Marvel‘s favorite frenemies are back in the second trailer for the hotly anticipated “Deadpool and Wolverine” — the third installment in the “Deadpool” series of films and the first set in the Marvel Cinematic Universe.

This time, Deadpool and Wolverine fight like bloody hell to the tune of Madonna’s “Like a Prayer.”

“I’m about to lose everything that I’ve ever cared about,” Deadpool tells Wolverine in the trailer, to which Wolverine responds, “Not my fucking problem.”

“Is that what you said when your world went to shit?” Deadpool retorts, provoking Wolverine to strike his crotch with those claws before Deadpool shoots him several times in the torso.

Cut to the two heroes chumming it up over lunch: “Wanna talk about what’s haunting you, or should we wait for a third act flashback?”

The threequel stars Ryan Reynolds’ Deadpool and brings back Hugh Jackman’s Wolverine, whom fans last saw die in 2017’s sendoff movie “Logan.” The movie will introduce the iconic claw-bearing mutant and Merc With a Mouth to the MCU.

“Deadpool and Wolverine” comes nearly six years after the release of “Deadpool 2,” during which time we’ve seen the wrap of Fox’s “X-Men” film series and Disney’s complete acquisition of 20th Century Fox (which held the rights to the X-Men and Fantastic Four — the latter now also getting its first MCU feature film.)

Anticipation for Deadpool’s latest film is brewing. The first trailer for “Deadpool and Wolverine,” which debuted during the Super Bowl, broke the record for the most-viewed movie trailer within 24 hours with an astounding 365 million total views, beating out the previous holder “Spider-Man: No Way Home.”

The raunchy, R-rated superhero film sees Deadpool arrive in the MCU after being kidnapped by the Time Variance Authority, the multiverse manager last seen in “Loki,” and finding himself in the same world as the Avengers.

Shawn Levy directs the film, which also stars Emma Corrin, Morena Baccarin, Rob Delaney, Leslie Uggams, Karan Soni and Matthew Macfadyen.

Kevin Feige, Reynolds, Levy and Lauren Shuler Donner produce “Deadpool and Wolverine,” with Louis D’Esposito, Wendy Jacobson, Mary McLaglen, Josh McLaglen, Rhett Reese, Paul Wernick, George Dewey, Simon Kinberg and Jonathon Komack Martin serving as executive producers. It’s written by Reynolds, Rhett Reese, Paul Wernick, Zeb Wells and Levy.

“Deadpool and Wolverine” hits theaters on July 26.